Alpha-ketoglutarate (AKG) is a critical compound found naturally in the body, especially within the Krebs cycle the series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of nutrients. As an intermediate in this cycle, AKG:
Because AKG levels decline significantly with age, this loss is associated with fatigue, muscle loss, slower recovery, and systemic aging. That's where supplementation with Calcium Alpha-Ketoglutarate (Ca-AKG) comes in.
AKG in its raw form is unstable and quickly breaks down, especially in acidic environments like the stomach. By binding AKG to calcium, it becomes a more bioavailable, stable, and effective supplement.
Calcium acts as:
This combination ensures that Ca-AKG can circulate effectively and enter cells where it fuels the mitochondria, enhances repair, and improves resilience.
Ca-AKG has exploded in popularity in the anti-aging and biohacking community, thanks to emerging research showing that it:
Researchers believe AKG acts as a caloric restriction mimetic, a compound that mimics the longevity benefits of fasting, without the need to dramatically reduce calories.
Miduty's Calcium Alpha-Ketoglutarate (Ca-AKG) offers a scientifically advanced form of calcium that combines 99% pure, highly bioavailable calcium with α-Ketoglutarate a key metabolic compound that enhances calcium absorption, promotes bone formation, supports muscle health, and boosts cellular energy. Unlike conventional calcium supplements like calcium carbonate or citrate, which depend on stomach acid for absorption and may increase the risk of arterial calcification, Miduty's Ca-AKG is designed to be gentle on digestion while supporting heart health.
Its fully water-soluble organic salt form allows for effortless absorption without the need for food or high stomach acid, making it ideal for those with digestive sensitivities or poor nutrient absorption. Additionally, Miduty's Ca-AKG is third-party tested for purity and safety, ensuring it is free from heavy metals, pesticides, and other contaminants often found in traditional calcium supplements.
Beyond strengthening bones, it helps retain essential minerals, reducing joint pain, stiffness, and the risk of osteoporosis. With its dual action of superior absorption and bone protection, Miduty's Calcium AKG offers a smarter, safer, and more effective solution for long-term skeletal and cellular health.
| Uses & Benefits | Description |
| Longevity and Cellular Energy Support |
Ca-AKG is a core compound in cellular respiration, meaning it: [1]
People use it to:
It’s especially effective when combined with:
|
| Muscle Function and Bone Mineral Density |
With aging, we lose muscle mass (sarcopenia) and bone density (osteopenia). Ca-AKG helps counteract this by: [2] [3]
Studies in aged mice show that Ca-AKG supplementation preserved lean muscle mass and improved strength. It also improves collagen cross-linking, which contributes to stronger connective tissues, joints, and tendons. [4] It’s especially valuable for:
|
| Detoxification and Metabolic Waste Removal |
AKG binds to nitrogen, making it essential for:
This makes Ca-AKG valuable in detox protocols or after periods of stress, heavy metal exposure, or high-protein intake. It works synergistically with:
|
| Fasting Mimicking and Caloric Restriction Mimetics |
Ca-AKG is one of the most promising fasting mimetics, meaning it activates the same cellular repair and anti-aging pathways triggered by fasting without food deprivation. It:
This makes it ideal for:
|
| Boosts Detox Pathways and Improves Skin, Gut, and Immune Resilience |
Ca-AKG supports total-body health by: [8]
It may result in fewer breakouts and brighter skin, better digestion and reduced bloating, strengthened immune resilience from the inside out. Its detox benefits also make it ideal for:
|
| Supports Mitochondrial Efficiency and ATP Production |
Ca-AKG:
This leads to:
|
| Extends Healthspan by Reducing Inflammaging |
One of the hallmark features of aging is chronic low-grade inflammation, or “inflammaging.” Ca-AKG has been shown to reduce: [9] [10]
In animal models, it increased lifespan by over 40% and improved overall health quality in late life stages. In humans, it’s reported to improve:
|
The most commonly studied human equivalent dose is 1,000 to 2,000 mg per day, preferably on an empty stomach.
This amount is sufficient to increase AKG plasma levels, Activate longevity pathway, support energy and metabolism without overstimulation.
Ca-AKG is safe at doses up to 3 grams/day, though most users benefit from 1-2 capsules daily.
It stacks well with electrolytes, antioxidants, and adaptogens depending on your protocol.
Ca-AKG is safe at doses up to 3 grams/day, though most users benefit from 1-2 capsules daily.
For maximum effectiveness, Ca-AKG is best taken during a fasting window or 30–60 minutes before your first meal. This mimics caloric restriction and enhances:
Taking it on an empty stomach also improves absorption and avoids competition with dietary amino acids.
However, if you experience stomach sensitivity, Ca-AKG can also be taken:
Morning is the most strategic time to take Ca-AKG because it:
It can also be used:
For longevity stacks, pair morning Ca-AKG with:
Ca-AKG is safe for long-term use, and many experts recommend:
This gentle cycle helps maintain sensitivity in the AKG and mTOR signaling pathways, much like fasting or workout variation.
Alternatively, some users follow a 5-day-on, 2-day-off pattern, especially when stacking with intensive protocols like detox, fasting, or endurance training.
Ca-AKG is generally very well tolerated, but in rare cases, users may experience:
To minimize issues:
Symptoms usually resolve within days as the body adapts to improved detox and mitochondrial activation.
Ca-AKG pairs exceptionally well with:
These combinations optimize cellular repair and build a complete anti-aging routine from the inside out.
For advanced users, consider these stacking protocols:
Rotate ingredients based on your goals, but keep Ca-AKG as the metabolic foundation.
Ca-AKG is ideal for:
It's also helpful for:
To Integrate It into Your Daily Longevity Stack
Calcium alpha-ketoglutarate supports bone strength, energy production, and healthy aging. As a naturally occurring compound, it plays a role in muscle building, wound healing, and may help prevent muscle loss after surgery or injury. It's also being explored for its potential anti-aging benefits.
Calcium alpha-ketoglutarate (Ca-AKG) is being studied for its potential to slow down signs of aging by supporting cellular health and reducing inflammation. While it may help promote healthier aging, more research is needed to confirm its ability to reverse aging.
Yes, calcium alpha-ketoglutarate is beneficial for bone health as it supports bone strength and density. It helps provide essential nutrients that contribute to maintaining healthy bones.
The recommended daily intake of calcium alpha-ketoglutarate usually falls between 300 mg and 1000 mg for adults. However, the exact dose may vary based on individual needs, so it's best to follow product instructions or consult a healthcare provider.
Alpha-ketoglutarate (AKG) may support kidney health by helping regulate nitrogen balance and reducing toxin buildup. Some studies suggest it can be beneficial during kidney stress, but more research is needed to confirm its long-term effects.
